NOT KNOWN DETAILS ABOUT FENTANYL TOXICITY SIGNS AND SYMPTOMS

ritlecitinib will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Ritlecitinib inhibits CYP3A4 substrates; coadministration raises AUC and peak plasma concentration sensitive substrates, which can enhance risk of adverse reactions.If coadministration of CYP3A4 inhibitors